Principal Investigators must fill out Request for Exemption from IRB Review Form for all research and teaching activities, that may be eligible for exemption from IRB review. (A list of examples of activities that qualify for Exempted review is available). Exemptions may be granted by ORIA for certain research projects. Research investigators cannot make the final determination of exemption from applicable Federal regulations or provisions of this Assurance for their own studies. Only ORIA can designate an activity as "exempt." All research involving human participants must therefore be submitted to ORIA for review. A determination of exemption is generally performed within one week's time.